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DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France

Maria Sormani 1 Marco Salvetti 2 Pierre Labauge 3 Irene Schiavetti 1 Helene Zephir 4 Luca Carmisciano 1 Caroline Bensa 5 Nicola de Rossi 6 Jean Pelletier 7 Cinzia Cordioli 6 Sandra Vukusic 8 Lucia Moiola 9 Philippe Kerschen 10 Marta Radaelli 11 Marie Théaudin 12 Paolo Immovilli Olivier Casez 13 Marco Capobianco Jonathan Ciron 14 Maria Trojano 15 Bruno Stankoff 16, 17 Alain Créange 18 Gioacchino Tedeschi 19 Pierre Clavelou 20 Giancarlo Comi 9 Eric Thouvenot 21, 22 Mario Battaglia 23 Thibault Moreau 24 Francesco Patti 25 Jérôme de Sèze 26 Celine Louapre 16, 27
Abstract : We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39-3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18-0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.
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Submitted on : Tuesday, July 13, 2021 - 9:23:38 AM
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Maria Sormani, Marco Salvetti, Pierre Labauge, Irene Schiavetti, Helene Zephir, et al.. DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France. Annals of Clinical and Translational Neurology, Wiley, 2021, 8 (8), pp.1738-1744. ⟨10.1002/acn3.51408⟩. ⟨hal-03285034⟩

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