Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response

Caroline Sevoz-Couche (1) , Maxime Patout (1, 2) , Beny Charbit (3) , Thomas Similowski (1, 2) , Christian Straus (1, 2)

1 UMRS 1158 - Neurophysiologie Respiratoire Expérimentale et Clinique
2 CHU Pitié-Salpêtrière [AP-HP]
3 HERVI - EA 3801 - Hémostase et Remodelage Vasculaire Post-Ischémie

After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment.

Keywords: Hypoventilation syndrome Desogestrel Autonomic nervous system Heart rate variability; Hypoventilation syndrome; Desogestrel; Autonomic nervous system; Heart rate variability

Domains: Life Sciences [q-bio]

Caroline Sevoz-Couche, Maxime Patout, Beny Charbit, Thomas Similowski, Christian Straus. Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response. Respiratory Research, 2024, 25, ⟨10.1186/s12931-023-02625-w⟩. ⟨hal-04465565⟩