FP09.05 Driver Oncogenic Alterations and Indoor Radon in NSCLC Patients From the IFCT Biomarker Cohort: Bioradon France Study

L. Mezquita (1, 2) , F. Barlesi (2, 3) , G. Ielsch (4) , J. Merlio (5) , D. Debieuvre (6) , J. Mosser (7) , C. Ricordel (7) , L'Houcine Ouafik (8, 9) , I. Rouquette (10) , I. Monnet (11) , F. Escande (12) , A. Langlais (13) , F. Morin (13) , C. Vignaud (14) , E. Auclin (15) , J.C. Benitez (2) , D. Planchard (2) , K. Leuraud (14) , D. Laurier (14) , B. Besse (2) , V. Westeel (16)

1 Department of Medical Oncology [Barcelona, Spain]
2 Département de médecine oncologique [Gustave Roussy]
3 CRCM - Centre de Recherche en Cancérologie de Marseille
4 IRSN/PSE-ENV/SEREN/BERAD - Bureau d'étude et d'expertise du radon
5 CHU Bordeaux
6 GHRMSA - Groupe hospitalier de la région de Mulhouse Sud-Alsace
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
8 INP - Institut de neurophysiopathologie
9 Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM]
10 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
11 CHI Créteil
12 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
13 IFCT - Intergroupe Francophone de Cancérologie Thoracique [Paris]
14 IRSN - Institut de Radioprotection et de Sûreté Nucléaire
15 HEGP - Hôpital Européen Georges Pompidou [APHP]
16 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon

Those with FH of LC were more likely to be obese regardless of demographic factors, and less likely to exercise 2+ times per week (Table). Those with FH of LC were more likely to have received 10+ imaging scans and to have been exposed to hydrocarbons compared to those without FH (Table). There were no reported differences in any other occupational or home exposures, including asbestos and radon in those with v. without FH of LC (Table). Conclusion: FH of LC is associated with higher-risk behaviors that increase the likelihood of developing both lung and other cancers. As such, FH can be used in cancer prevention and control programs to identify higher-risk patients and educate patients that FH of lung cancer is associated with risk-increasing behaviors that are nonetheless modifiable.

Keywords: Family History; Risky Behaviors; Prevention

Domains: Cancer

L. Mezquita, F. Barlesi, G. Ielsch, J. Merlio, D. Debieuvre, et al.. FP09.05 Driver Oncogenic Alterations and Indoor Radon in NSCLC Patients From the IFCT Biomarker Cohort: Bioradon France Study. Journal of Thoracic Oncology, 2021, 16 (3), pp.S214. ⟨10.1016/j.jtho.2021.01.122⟩. ⟨hal-03603784⟩