Impact of lymphovascular invasion on otherwise low-risk papillary thyroid carcinomas: a retrospective and observational study

Recommandations conjointes du réseau National ENDOCAN-COMETE, de l’Association francophone de chirurgie endocrinienne et de la Société française d’urologie pour la prise en charge du carcinome corticosurrénalien

Rossella Libé (1, 2) , Magalie Haissaguerre (3) , Karine Renaudin (4) , Matthieu Faron (5, 6, 7) , Myriam Decaussin-Petrucci (8) , Fréderic Deschamps (5) , Anne-Paule Gimenez-Roqueplo (9) , Eric Mirallié (4, 10) , Thibaut Murez (11) , François Pattou (12) , Laurence Rocher (13) , David Taïeb (14, 15, 16) , Pierre Henri Savoie (17) , Antoine Tabarin (3) , Jérôme Bertherat (2) , Eric Baudin (5) , Christelle De La Fouchardière (18)

1 IC UM3 (UMR 8104 / U1016) - Institut Cochin
2 Hôpital Cochin [AP-HP]
3 Hôpital Haut-Lévêque [CHU Bordeaux]
4 Hôtel-Dieu de Nantes
5 IGR - Institut Gustave Roussy
6 U1018 (Équipe 2) - Oncostat
7 CESP - Centre de recherche en épidémiologie et santé des populations
8 HCL - Hospices Civils de Lyon
9 HEGP - Hôpital Européen Georges Pompidou [APHP]
10 Institut des Maladies de l'Appareil Digestif
11 CHU Montpellier
12 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
13 AP-HP - Hôpital Antoine Béclère [Clamart]
14 TIMONE - Hôpital de la Timone [CHU - APHM]
15 AMU - Aix Marseille Université
16 CERIMED - Centre Européen de Recherche en Imagerie médicale
17 HIA - Hopital d'instruction des armées Sainte-Anne [Toulon]
18 Centre Léon Bérard [Lyon]

The adrenocortical carcinoma (ACC) is a primary malignant tumor developed from the adrenal cortex, defined by a Weiss score≥3. Its prognosis is poor and depends mainly on the stage of the disease at diagnosis. Care is organized in France by the multidisciplinary expert centers of the national ENDOCAN-COMETE "Adrenal Cancers" network, certified by the National Cancer Institute. This document updates the guidelines for the management of ACC in adults based on the most robust data in the literature. It's divided into 11 chapters: (1) circumstances of discovery; (2) pre-therapeutic assessment; (3) diagnosis of ACC; (4) oncogenetics; (5) prognostic classifications; (6) treatment of hormonal hypersecretion; (7) treatment of localized forms; (8) treatment of relapses; (9) treatment of advanced forms; (10) follow-up; (11) the particular case of ACC and pregnancy. R0 resection of all localized ACC remains an unmet need and it must be performed in expert centers. Flow-charts for the therapeutic management of localized ACC, relapse or advanced ACC are provided. It was written by the experts from the national ENDOCAN-COMETE network and validated by all French Societies involved in the management of these patients (endocrinology, medical oncology, endocrine surgery, urology, pathology, genetics, nuclear medicine, radiology, interventional radiology).

Mots clés: Adrenocortical carcinoma; Diagnosis; Follow-up; Guidelines; Treatment

Domaines: Cancer; Méthodes et statistiques; Statistiques [stat]; Autres [stat.ML]; Méthodologie [stat.ME]

Rossella Libé, Magalie Haissaguerre, Karine Renaudin, Matthieu Faron, Myriam Decaussin-Petrucci, et al.. Impact of lymphovascular invasion on otherwise low-risk papillary thyroid carcinomas: a retrospective and observational study. Bulletin du Cancer, 2023, 110 (10), pp.707 - 730. ⟨10.1016/j.bulcan.2023.03.015⟩. ⟨inserm-04500838⟩